Scientists have discovered that the enzyme aconitate decarboxylase 1 (ACOD1) is not an anti-inflammatory mediator in sepsis. In the presence of bacterial toxins, it is involved in the cytokine storm and inflammatory signaling in monocytes and macrophages, becoming a potential therapeutic target against the infection. This proinflammatory role is the opposite of ACOD1's previously known…
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“Anti-inflammatory” enzyme plays proinflammatory role in sepsis





